Drug Metabolism | Exploring Biochemical Processes for Safer and More Effective Treatments

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Drug Metabolism is a critical field of study that explores the biochemical processes by which the body transforms pharmaceutical compounds. This discipline investigates the enzymatic pathways involved in the absorption, distribution, metabolism, and excretion (ADME) of drugs. Understanding drug metabolism is fundamental to drug development, as it determines the efficacy, safety, and potential side effects of therapeutic agents. By studying the enzymes responsible for drug biotransformation, researchers can predict how drugs interact within the body, identify genetic variations that influence metabolism, and optimize dosing regimens.

The study of drug metabolism also has profound implications for personalized medicine, as individual genetic differences can affect how drugs are processed and how they impact different patients. Furthermore, drug metabolism research informs the design of new drugs, helping scientists to overcome issues of drug toxicity, drug resistance, and interactions with other medications. It is a dynamic and interdisciplinary field at the intersection of pharmacology, biochemistry, and toxicology, playing a pivotal role in advancing therapeutic strategies and improving public health outcomes.

Cytochrome P450 enzymes and drug metabolism Phase I and Phase II drug metabolism Genetic polymorphisms in drug metabolism Metabolic pathways of xenobiotics Drug-drug interactions and metabolism Pharmacokinetics and pharmacodynamics Biotransformation of bioactive compounds Metabolism of biologics and peptides Toxicology and drug metabolism Influence of diet and nutrition on drug metabolism Hepatic metabolism of drugs Metabolomics in drug discovery Metabolism in disease states (e.g. liver disease) Drug metabolism in aging populations Transporters and their role in drug metabolism Immunoassays in drug metabolism studies Metabolic fate of environmental toxins In vitro and in vivo models of drug metabolism The role of gut microbiota in drug metabolism Regulatory considerations in drug metabolism studies

Biology Group (1)

Short Communication Article ID: igmin177

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by Sanaa Qasem Badr

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